But the majority of patients were battling multisystem organ failure, and their prognoses were not good. 但是大多数患者都是多器官功能衰竭,其预后都不是很好。
Although majority of the tumor come from monoclone, as a result of the tumor genetics instability and the target organ selective action, the performance of tumors variate unceasingly and some subclone obtains the metastatic phenotype. 虽然大多数肿瘤是单克隆起源的,但由于肿瘤的遗传学不稳定性和靶器官的选择作用,肿瘤常常表现为一个不断变异的群体,有些瘤细胞亚群得以杂在靶器官优势生长,获得转移表型。
For chemotherapy, as the majority of HCC cells was tolerance to chemotherapy drugs. Increased the dose of chemotherapy drugs in patients would cause systemic toxicity and caused multiple organ failure. 对于化疗来说,由于大多数肝癌细胞对化疗药物不敏感,增加化疗药物的剂量会造成患者全身的毒副作用,引发多器官功能衰竭。